Duphaston contains Dydrogesterone which is an artificial progesterone.

Duphaston pills


This medication is used for the treatment of many conditions caused due to a deficiency of progesterone hormone such as secondary amenorrhea, menstrual disorders, dysmenorrheal, unusual uterine bleeding, premenstrual syndrome which occurs during the menstrual periods. Duphaston is also used for the treatment of endometriosis, spontaneous abortion and infertility. Progesterone is a hormone present in females which is responsible for the growth of the endometrial lining. Duphaston is used to mimic the working of progesterone in several medical conditions.

How To Use

Take Duphaston with/without food, with a glass full of water, generally once or twice in a day. The dosage of Duphaston you take is based on the response to therapy and medical condition. You should continue the use of this medication according to the doctor’s recommendations. For irregular and painful menstruation, take 10 mg two times in a day starting from the fifth day of periods till the 25th day. To treat endometriosis, 10 mg is recommended twice or thrice every day. Take this medicine 10 mg twice every day for a week to treat unexpected or dysfunctional bleeding. To treat secondary amenorrhea, take this medicine with estrogen combination in a 10 mg quantity twice every day. In case of abortion, take 40 mg immediately and then doses of 10 mg for every 8 hours. To treat infertility, take this medicine 10 mg in a day.

Side Effects

The most common aftereffects which are reported during the use of Duphaston tablets are: weight gain, nausea, breast pain, skin rashes, bloating, pulsating headache, migraines, blood spotting, irregular periods, pain during menstrual periods, missed periods, heavy bleeding during menstruation, hypersensitivity, depression, fatigue, distention, emotional lability, abdominal pain, irritability, breakthrough bleeding, skin reactions, menstrual changes, weight change, oedema, confusion, hepatitis, retinal thrombosis, vision disturbances, hair abnormalities, slurred speech, shortness of breath, optic neuritis, thrombophlebitis, liver tumors, hypertension, gall bladder problems, pulmonary embolism, congenital abnormalities, neuro-ocular lesions, cerebral thrombosis, cerebral hemorrhage, mesenteric thrombosis, breast tenderness, weight gain, abnormal liver problem, jaundice, abdominal discomfort, irregular bleeding, itching and dizziness.


This drug is contraindicated in patients with undiagnosed unusual vaginal bleeding, breast cancer, stroke, blood clot disorder, missed abortion, cerebrovascular disease, epilepsy, migraine, asthma, kidney impairment, fluid retention, clinical depression, coronary artery disease, brain cancer, hepatic disease, cancer of genital organs, pruritus, herpes, sickle cell anemia, cholestatic jaundice, thrombophlebitis, liver dysfunction, hypersensitivity, and incomplete abortion and breastfeeding women. A mammogram should be conducted regularly to keep a check on breast cancer. Patients suffering from psychic depression should be examined carefully and the medicine should be discontinues if the depression reappears. This drug should not be used in children below the age of 18 years. Duphaston should not be administered to patients with a history of thromboembolic disorders.

Pregnancy And Duphaston

There are no well-controlled and adequate studies of the harmful effects of this drug in pregnant females. Duphaston is excreted into the maternal milk. Thus do not use Duphaston during breast-feeding your infant.

Drug Images

Duphaston blister


Dydrogesterone is a synthetic hormone similar to the progesterone hormone naturally produced by the body. It's primarily used in hormone replacement therapy (HRT) and for treating various gynecological conditions. Dydrogesterone is prescribed for several purposes:

  • Menstrual Disorders: It is used to regulate irregular menstrual cycles and manage conditions like irregular periods, painful periods (dysmenorrhea), and premenstrual syndrome (PMS).
  • Infertility and Assisted Reproduction: Dydrogesterone is sometimes prescribed as part of assisted reproduction techniques like in vitro fertilization (IVF) to support the uterus during implantation and early pregnancy.
  • Threatened or Recurrent Miscarriage: It may be used in cases of threatened or recurrent miscarriage to support the uterus and help maintain a pregnancy.
  • Hormone Replacement Therapy (HRT): Dydrogesterone can be included in hormone replacement therapy for menopausal women, particularly in combination with estrogen to protect the uterus from the effects of estrogen alone.